VUS Program
Support for families told they carry a "variant of uncertain significance" in RNU4-2 or RNU6.
About the VUS program
A variant of uncertain significance (VUS) is a genetic change that has been found but not yet confirmed to cause disease. For families, a VUS result can be one of the most confusing and frustrating outcomes of genetic testing — neither a clear answer nor a clear all-clear.
Because RNU4-2 and RNU6 retinal disease was only recently discovered, many variants in these genes are still being classified. The CURE4/6 VUS program as part of the U4/U6 Registry aims to help affected families and their clinicians make sense of these results and contribute to the research that reclassifies them.
By joining the U4/U6 Registry we will update you as more of the VUS's are determined to cause disease.